Warning in read.ods("Antipsychotics.ods", sheet = 1): read.ods will be
deprecated in the next version. Use read_ods instead.Antipsychotics
Psychiatry
Dopamin-Rezeptoren
- D_1/D_5-Gruppe: Signalübertragung durch stimulatorisches G-Protein –> cAMP hoch
- D_2/D_3/D_4-Gruppe: Signalübertragung durch hemmendes G-Protein –> cAMP runter
Wichtige dopaminerge Neuronensysteme
- Nigrostriatales System: Motorik (damit auch EPS)
- Mesolimbisches / mesokortikales System: Hauptangriffsort der Antipsychotika
- Tuberoinfundibuläres System: vermittelt die neuroendokrinologischen NW, insbesondere Prolaktin-Anstieg
Antipsychotika
| Substanz | Klasse | Trizyklisch | Typ | Potenz | D1 | D2 | D3 | Ser2 | M1 | alpha1 | H1 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Amisulprid | Benzamid | 0 | AAP | NA | 0 | 3 | 3 | 0 | 0 | 0 | 0 |
| Aripiprazol | Phenylpiperazinylcholin | 0 | AAP | NA | 0 | 3 | 3 | 2 | 0 | 1 | 1 |
| Asenapin | Dibenzooxepinpyrrol | 0 | AAP | NA | 1 | 1 | 2 | 2 | 0 | 1 | 1 |
| Benperidol | Butyrophenon | 0 | KAP | HP | 0 | 3 | 2 | 2 | 0 | 1 | 0 |
| Bromperidol | Butyrophenon | 0 | KAP | HP | 1 | 3 | 2 | 0 | 0 | 1 | 0 |
| Chorprothixen | Thioxanthen | 1 | KAP | NP | 2 | 1 | 1 | 2 | 1 | 1 | 3 |
| Clozapin | Dibenzodiazepin | 1 | AAP | NA | 2 | 1 | 2 | 3 | 3 | 1 | 3 |
| Flupentixol | Thioxeanthen | 1 | KAP | HP | 2 | 3 | 3 | 2 | 0 | 1 | 1 |
| Fluphenazin | Phenothiazin | 1 | KAP | HP | 2 | 3 | 3 | 2 | 0 | 2 | 2 |
| Fluspirilen | Diphenylbutylpiperidin | 0 | KAP | HP | 1 | 3 | 2 | 1 | 0 | 0 | 0 |
| Haloperidol | Butyrophenon | 0 | KAP | HP | 2 | 3 | 2 | 1 | 0 | 2 | 0 |
| Levomepromazin | Phenothiazin | 1 | KAP | NP | 0 | 1 | 1 | 1 | 2 | 2 | 2 |
| Loxapin | Dibenzoxazepin | 1 | KAP | MP | 0 | 3 | 1 | 3 | 2 | 3 | 3 |
| Lurasidon | Benzoisothiazol | 0 | AAP | NA | 1 | 3 | 2 | 3 | 0 | 2 | 0 |
| Melperon | Butyrophenon | 0 | KAPA | NP | 0 | 1 | 1 | 2 | 0 | 1 | 1 |
| Olanzapin | Thienobenzazepin | 1 | AAP | NA | 2 | 3 | 2 | 3 | 2 | 2 | 3 |
| Paliperidon | Benzisoxazol | 0 | AAP | NA | 0 | 3 | 1 | 3 | 0 | 1 | 1 |
| Perazin | Phenothiazin | 1 | KAP | MP | 0 | 2 | 2 | 2 | 1 | 2 | 3 |
| Perphenazin | Phenothiazin | 1 | KAP | HP | 0 | 3 | 3 | 2 | 0 | 2 | 2 |
| Pimozid | Diphenylbutylpiperidin | 0 | KAP | HP | 0 | 3 | 3 | 2 | 0 | 0 | 0 |
| Pipameron | Butyrophenon | 0 | KAP | NP | 0 | 1 | 1 | 2 | 0 | 1 | 0 |
| Prothipendyl | Phenothiazin | 1 | KAP | NP | NA | 1 | NA | NA | NA | NA | NA |
| Quetiapin | Dibenzothiazepin | 1 | AAP | NA | 1 | 1 | 1 | 1 | 0 | 1 | 2 |
| Risperidon | Benzisoxazol | 0 | AAP | NA | 2 | 3 | 2 | 3 | 0 | 3 | 1 |
| Sertindol | Indol | 0 | AAP | NA | 2 | 3 | 1 | 3 | 0 | 2 | 0 |
| Sulpirid | Benzamid | 0 | KAPA | MP | 0 | 1 | 3 | 0 | 0 | 0 | 0 |
| Thioridazin | Phenothiazin | 1 | KAP | NP | 1 | 2 | 1 | 2 | 3 | 3 | 1 |
| Ziprasidon | Benzisothiazin | 0 | AAP | NA | 1 | 2 | 2 | 3 | 0 | 1 | 2 |
| Zuclopenthixol | Thioxanthen | 1 | KAP | MP | 2 | 3 | 2 | 0 | 3 | 3 | 3 |
| Substanz | Klasse | Trizyklisch | Typ | Potenz | D1 | D2 | D3 | Ser2 | M1 | alpha1 | H1 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Amisulprid : 1 | Phenothiazin : 6 | Min. :0.0000 | AAP :11 | HP : 8 | Min. :0.0000 | Min. :1.000 | Min. :1.000 | Min. :0.000 | Min. :0.0000 | Min. :0.000 | Min. :0.00 | |
| Aripiprazol : 1 | Butyrophenon : 5 | 1st Qu.:0.0000 | KAP :16 | MP : 4 | 1st Qu.:0.0000 | 1st Qu.:1.000 | 1st Qu.:1.000 | 1st Qu.:1.000 | 1st Qu.:0.0000 | 1st Qu.:1.000 | 1st Qu.:0.00 | |
| Asenapin : 1 | Benzamid : 2 | Median :0.0000 | KAPA: 2 | NP : 6 | Median :1.0000 | Median :3.000 | Median :2.000 | Median :2.000 | Median :0.0000 | Median :1.000 | Median :1.00 | |
| Benperidol : 1 | Benzisoxazol : 2 | Mean :0.4483 | NA | NA’s:11 | Mean :0.8929 | Mean :2.276 | Mean :1.929 | Mean :1.857 | Mean :0.6071 | Mean :1.429 | Mean :1.25 | |
| Bromperidol : 1 | Diphenylbutylpiperidin: 2 | 3rd Qu.:1.0000 | NA | NA | 3rd Qu.:2.0000 | 3rd Qu.:3.000 | 3rd Qu.:2.250 | 3rd Qu.:3.000 | 3rd Qu.:1.0000 | 3rd Qu.:2.000 | 3rd Qu.:2.00 | |
| Chorprothixen: 1 | Thioxanthen : 2 | Max. :1.0000 | NA | NA | Max. :2.0000 | Max. :3.000 | Max. :3.000 | Max. :3.000 | Max. :3.0000 | Max. :3.000 | Max. :3.00 | |
| (Other) :23 | (Other) :10 | NA | NA | NA | NA’s :1 | NA | NA’s :1 | NA’s :1 | NA’s :1 | NA’s :1 | NA’s :1 |